Israel launched a wave of strikes across Iran on Friday that targeted its nuclear program and military sites, killing at least two top military officers and raising the prospect of an all-out war between the two bitter Middle East adversaries. It appeared to be the most significant attack Iran has faced since its 1980s war with Iraq.

The strikes came amid simmering tensions over Iran’s rapidly advancing nuclear program and appeared certain to trigger a reprisal. Hours later, Israel’s military said it had begun intercepting Iranian drones launched in retaliation.

What To Know:

• Israel is targeting Iran’s nuclear sites: Israeli Prime Minister Benjamin Netanyahu said that Israel targeted Iran’s main enrichment facility in Natanz and the country’s ballistic missile program, as well as top nuclear scientists and officials.
• Head of Iran’s paramilitary Revolutionary Guard is feared dead: The report from Iranian state television offered few other details about what happened to Gen. Hossein Salami. Iran’s Revolutionary Guard, created after its 1979 Islamic Revolution, is one of the main power centers within the country’s theocracy.
• Tensions rose over Iran’s nuclear program: The Board of Governors at the International Atomic Energy Agency censured the nation for the first time in 20 years Thursday after it refused to work with inspectors. Iran immediately announced it would establish a third enrichment site in the country and swap out some centrifuges for more advanced ones.
• US responds with a warning: U.S. Secretary of State Marco Rubio said Israel took “unilateral action against Iran,” warning Iran not to target U.S. forces in retaliation. In recent days, the U.S. began pulling some diplomats from Iraq’s capital and offering voluntary evacuations for the families of U.S. troops in the wider Middle East.

—-AP